Proof of postmenopausal osteoporosis
The main clinical manifestations of this disease are: waist, back, pain in the limbs, fatigue, severe activity and even bedridden; easy to cause fractures due to minor trauma, diffuse bone tenderness can be found; hunchback or body shortened or compression fracture.
In biochemical indicators, serum osteocalcin (BGP), osteocalcin, is synthesized by osteoblasts and is an important indicator of bone formation. Serum alkaline phosphatase (AKP) is produced by osteoblasts or liver, and their activities are different.In normal liver function, it can be used as an indicator of bone formation; and the ratio of urinary calcium/creatinine (vca / cr) is an indicator of bone resorption.
The above indicators are higher than normal, lower than normal or in the normal range, respectively reflecting the shortening of the bone reconstruction cycle, extending or near normal.
Postmenopausal osteoporosis is the absorption of bone beyond bone formation.
Nutritional factors play an additional role in the development of postmenopausal osteoporosis and have a certain impact on the occurrence of senile osteoporosis.
Mainly due to calcium deficiency, the reasons are: (1) insufficient long-term calcium supplementation.
Domestic and external nutrition survey materials indicate that the expected amount of calcium generally exceeds the standard amount.
The activities and food intake of the elderly are reduced, and calcium is more scarce.
(2) Absorptive, due to lack of outdoor activities and receiving sunlight, vitamin D deficiency, 1.
The production of 25-(oH)2vDs is reduced in Nigeria, affecting the absorption of calcium by interactions.
In addition, the activity of the elderly is reduced, the osteoblasts are reduced, and the activity of osteoclasts is relatively enhanced, and bone resorption is increased, which is one of the factors of primary osteoporosis.
The main measures for correction are: (1) intake of sufficient calcium is the most basic method of osteoporosis.
To prevent bone loss in postmenopausal women, the calcium requirement is 1500 mg/day, and women over 65 should also increase to 2500 mg/day.
In order to prevent bone loss in the case of fasting at night, it is advisable to drink milk or take calcium before going to bed every night.
(2) hormone replacement therapy.
It is best to use natural, short-acting, oral estrogen preparations.
Such as estradiol valerate, micronized estradiol 1-2 mg / day, estrogen 0.
625 mg / g, when the calcium intake reaches 1500 mg / g, the hormone can be reduced by half.
The commonly used synthetic hormone in the country is nylestradiol, which is an estriol derivative, oral 2 mg / 2 weeks, ethinyl estradiol 0.
005 mg / day, progesterone 2 mg / day, alternately taken every other day.
In summary, pay attention to nutrition, make up the amount of calcium and strengthen exercise, is the basic means to correct postmenopausal osteoporosis, radical replacement therapy also has a special effect, should be carried out under the guidance of a doctor.